About us
Our overall aim is to understand the (epi)genetic, molecular and cellular pathophysiology of these disorders and to translate this knowledge into clinical applications such as diagnostic and prognostic biomarkers and novel treatments.
The department has a strong focus on optimisation of diagnosis and treatment of athero-thrombotic cardiometabolic diseases. The Experimental Vascular Medicine has a long-lasting reputation on early translational research of innovative therapies in humans (gene therapy, antisense, small molecules), surrogate marker studies for cardiovascular disease (ultrasound, MRI, stable isotope fluxes), diagnostic studies (thrombosis/pulmonary embolism) and RCTs in cardiometabolism. The research conducted at the department is done in close collaboration with the Department of Vascular Medicine.
In addition, a dedicated clinical/research program for patients with cardiovascular genetic diseases (lipids, thrombosis, premature atherosclerosis and diabetes) has been implemented. Also, the Microbiota Center Amsterdam (MiCA) is based here. The ambition of the department is to unravel novel mechanisms contributing to cardiometabolic disease, as well as to evaluate novel diagnostic and therapeutic strategies by applying systems medicine and machine learning approaches.
Research
The main research lines comprise the following:
- Atherosclerotic vascular disease is a chronic low-grade inflammatory process with a clinically silent period of decades.
- Obesity and insulin resistance are involved in the development of diabetes mellitus.
- (Venous) thrombo-embolic diseases provide another key area of research.
For more information about research, visit amsterdamumc.org/research
For more information about research output registration, visit researchinformation.amsterdamumc.org
Education
For more information about education, visit amsterdamumc.org/education
Patient Care
For more information about patient care, visit amsterdamumc.nl
Team
For information about our researchers, visit amsterdamumc.org/researchers
Career
We are always on the lookout for talented and passionate people to join our growing team. You will have the opportunity to develop any aspects you are interested in.
See all our vacancies (in Dutch): werkenbij.amsterdamumc.org
Contact
- A.M. Vree, G1-146 P.O. box 22660, 1100 DD Amsterdam The Netherlands
e-mail: a.m.vree@amsterdamumc.nl
Telephone: +31(0)20 5662824
- Head: Prof. M. Nieuwdorp PhD, MD
e-mail: mailto:m.nieuwdorp@amsterdamumc.nl