Amsterdam institute for Immunology and Infectious diseases

Cyster's lab studies how cells and antigens come together to generate immune responses. This involves a focus on deciphering the cues that guide immune cell movements within, and egress from, lymphoid organs. Furthermore, his lab has a strong interest in understanding how cell interaction dynamics influence the selection events underlying antibody affinity maturation. For visualizing immune response dynamics they use advanced imaging and cell engineering approaches for the in vivo quantitation of cell-cell interaction and cell signaling in germinal centers. Their studies are also informative about pathways leading to lymphomagenesis.
In addition, they study requirements for mounting long-lived antibody (plasma cell and memory B cell) responses and the derangements associated with autoantibody responses. His lab also explores requirements for barrier immunity at epithelial surfaces and characterizes the cellular dynamics underlying mucosal immune responses