Specialization
Focus of research
Lihui Guo works with Prof. Rene Lutter (Group Leader), Marianna Bugiani (Neuropathology), and also with Jan Willem W. Duitman (also group leader) in the Lung Group at the Dept. of Experimental Immunology, Amsterdam UMC, location AMC, University of Amsterdam.
Research focuses on the role of IDO1/2 in infectious diseases, such as tuberculosis, tuberculous meningitis (TBM), fatal/severe COVID-19, and post-COVID, post-acute sequelae of SARS-CoV-2 infection (PASC), also called “long COVID”(collaborative with Brent Appelman and Prof. Michèle van Vugt).
I am also deeply passionate about pathology, particularly in the realm of Neutrophil Extracellular Traps (NETs) and the impact of tryptophan metabolic stress on infectious diseases. Additionally, my interests extend to the study of Allergy (MMP-12) (Lara Ravanetti) and innovative treatments for Esophagogastric Cancer (EGC) (Dajia Liu).
As of tuberculosis (M. tuberculosis), using cell lines, a murine model, zebrafish model (Eva Habjan, and Prof. Wilbert Bitter), and IHC staining lung (Xiaohong Chen)and Brain (Stefan-Dan Zaharie,Marceline van Furth and Martijn van der Kuip) from TB patients, particularly focus on the role of IDO1 activity in macrophages protects M. tuberculosis from being killed by antibiotics (this project is collaborative with Nicole van der Wel), the role of IDO1 activity in manipulated apoptosis of M. tuberculosis infected macrophages, and using EM to study M. tuberculosis translocation within macrophages.