Specialization

Pediatric Neuroscientist

Focus of research

Marsh Königs (1987) is assistant professor in developmental neuroscience at Emma Children’s Hospital of Amsterdam UMC. He is educated in Biomedical Sciences (BSc), Cognitive Neuropsychology (MScRes, cum laude) and Clinical Neuropsychology (MSc, cum laude). Marsh obtained his PhD degree (2016, cum laude) for his research on the impact of pediatric traumatic brain injury on brain structure, neurocogition and behavior. His current research focuses on the impact of disease and treatment on brain structure and function of children, in the context of daily life problems. Marsh specializes in computerized neurocognitive test development, advanced analysis of task performance, advanced neuroimaging with magnetic resonance imaging and eye-tracking for early cognitive assessment in infants. 

 

Marsh Königs is senior researcher at the Emma Neuroscience group, currently supervising 6 PhD students. Marsh also acts as director of science at the Daan Theeuwes Center for Intensive Neurorehabilitation, is member of the Dutch Work Group on Brain Injury in Children and Young Adults (HEJ!) and is secretary of the organizing committee of the Amsterdam Kindersymposium.

 

Clinical Neuroscience in Children
Together with prof. dr. Jaap Oosterlaan, dr. Marsh Königs initiates and supervises neuroscientific research in the field of pediatrics. This research is focused on the impact of disease and intervention on the structure and function of the child’s brain. Dr. Königs specializes in the use and development of computerized neurocognitive tests, advanced analysis of neurocognitive test performance, eye-tracking and advanced magnetic resonance imaging of brain connectivity. The ultimate goal of his work is to contribute to clinical practice through (i) a better understanding of impairment mechanisms, (ii) improved outcome prediction (e.g. development of prognostic models using machine learning algorithms), (iii) evaluation of treatment efficacy in existing and novel interventions and (iv) development of outcome measures (e.g. neurocognitive test development).

Eye-tracking
Together with colleagues at the Universiteit van Amsterdam (Ingmar Visser & Maartje Raijmakers), Marsh develops a battery of tests to measure early cognitive functioning in babies and infants between 4-24 months. The goals is to provide sensitive measures for neurocognitive development with robust predictive value for outcome later in life.

Advanced Computerized Neurocognitive Testing
Dr. Königs specializes in the use and development of computerized neurocognitive tests and advanced analysis of task performance (e.g. Ex-Gaussian analysis, diffusion model analysis). Work in progress is Emma's Toolbox, an in-house designed battery of computerized tests to measure neurocognitive functions in children. Emma Toolbox involves a fixed core battery that uses parametric difficulty manipulation and built-in contrast conditions to isolate neurocognitive processes in the following domains: information processing, attention, learning and memory, executive functioning, sensory functioning and motor functioning. The core battery can be expanded with modules for further assessment of specific neurocognitive functions of interest, such as emotion recognition, language or visual short term memory. Emma Toolbox is an expanding battery: new modules become available by continuous test development.

Magnetic Resonance Imaging (MRI) of Brain Connectivity
Advanced MRI sequences are used to study the impact of disease and treatment on white matter integrity and brain connectivity. Based on diffusion tensor imaging, tract-based statistics is used to study white matter integrity, while structural connectivity is studied by probabilistic fiber tracking in combination with graph theory. Resting-state functional MRI is used to measure functional brain connectivity, using independent component analysis of resting-state networks as well as graph theory.

Commissions

  • Member of the National Workgroup for Acquired Brain Injury in Youth (HEJ!)
  • Secretary of the organizing committee of the Amsterdam Kindersymposium