Onno Holleboom

MD PhD

Medical Specialist, ACS - Diabetes & Metabolism Affiliatie UvA Medical Specialist, Amsterdam Gastroenterology Endocrinology Metabolism Medical Specialist, Vascular Medicine

PI

Specialization

Endocrinology and Metabolism; Vascular Medicine

Focus of research

Translational projects in non-alcoholic fatty liver disease, supported by Amsterdam UMC Fellowship 2018:

- innovation of multidisciplinary care

- ANCHOR: Amsterdam NAFLD-NASH cohort study @ AMC & VUmc

- LITMUS EU biobank (AMC: Dutch lead center)

- NILE project: prevalence and genetics of NAFLD in the multiethnic Helius cohort

- CRISTINA exercise intervention study in NAFLD

- lipid and liver pathways in rare metabolic diseases, with a focus on defects in lipophagy

- BARNARD: probiotics in mouse models of NAFLD

Latest publications

Development of a novel non-invasive biomarker panel for hepatic fibrosis in MASLD
Verschuren, L., Mak, A. L., van Koppen, A., Özsezen, S., Difrancesco, S., Caspers, M. P. M., Snabel, J., van der Meer, D., van Dijk, A-M., Rashu, E. B., Nabilou, P., Werge, M. P., van Son, K., Kleemann, R., Kiliaan, A. J., Hazebroek, E. J., Boonstra, A., Brouwer, W. P., Doukas, M., Gupta, S., & 7 othersKluft, C., Nieuwdorp, M., Verheij, J., Gluud, L. L., Holleboom, A. G., Tushuizen, M. E. & Hanemaaijer, R., Dec 2024, In: Nature communications. 15, 1, p. 4564 4564.
Research output: Contribution to journal › Article › Academic › peer-review
Diagnostic accuracy of non-invasive tests to screen for at-risk MASH-An individual participant data meta-analysis
Mózes, F. E., Lee, J. A., Vali, Y., Selvaraj, E. A., Jayaswal, A. N. A., Boursier, J., de Lédinghen, V., Lupșor-Platon, M., Yilmaz, Y., Chan, W-K., Mahadeva, S., Karlas, T., Wiegand, J., Shalimar, Tsochatzis, E., Liguori, A., Wong, V. W-S., Lee, D. H., Holleboom, A. G., van Dijk, A-M., & 24 othersMak, A. L., Hagström, H., Akbari, C., Hirooka, M., Lee, D. H., Kim, W., Okanoue, T., Shima, T., Nakajima, A., Yoneda, M., Thuluvath, P. J., Li, F., Berzigotti, A., Mendoza, Y. P., Noureddin, M., Truong, E., Fournier-Poizat, C., Geier, A., Tuthill, T., Yunis, C., Anstee, Q. M., Harrison, S. A., Bossuyt, P. M. & Pavlides, M., Aug 2024, In: Liver international. 44, 8, p. 1872-1885 14 p.
Research output: Contribution to journal › Article › Academic › peer-review
Validation of the enhanced liver fibrosis (ELF)-test in heparinized and EDTA plasma for use in reflex testing algorithms for metabolic dysfunction-associated steatotic liver disease (MASLD)
van Son, K. C., van Dijk, A-M., Driessen, S., Mak, A. L., Witjes, J. J., Houttu, V. A. T., Zwirs, D., Nieuwdorp, M., van den Born, B-J. H., Fischer, J. C., Tushuizen, M. E., Drenth, J. P. H., Hamer, H. M., Beuers, U. H. W., Verheij, J. & Holleboom, A. G., 15 May 2024, (E-pub ahead of print) In: Clinical chemistry and laboratory medicine.
Research output: Contribution to journal › Article › Academic › peer-review
All publications

Onno Holleboom

Specialization

Focus of research

Development of a novel non-invasive biomarker panel for hepatic fibrosis in MASLD

Diagnostic accuracy of non-invasive tests to screen for at-risk MASH-An individual participant data meta-analysis

Validation of the enhanced liver fibrosis (ELF)-test in heparinized and EDTA plasma for use in reflex testing algorithms for metabolic dysfunction-associated steatotic liver disease (MASLD)

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