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Proof of concept for Amsterdam UMC-led HIV vaccination Worldwide, an estimated 40 million people live with HIV, two-thirds living on the African continent. In 2023, more than 600,000 people died from HIV-related causes and 1.32 million became infected. There is no vaccine against the world's second most deadly infection – only tuberculosis kills more people. However, researchers from Amsterdam UMC have taken an important step towards reaching the goal of an HIV vaccine. The results of their phase one trial are published today in Science.
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No increased risk of gynaecological cancer with testosterone use in the first years Transmasculine and gender-diverse individuals who use testosterone are not at increased risk of gynecological cancer in the first years of hormone therapy. This is evident from large-scale research by Amsterdam UMC, which was published today in eClinicalMedicine. The results provide important insights for healthcare providers and transmasculine and gender-diverse individuals who are considering starting hormone therapy.
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New test diagnoses bacterial meningitis faster and better Researchers at Amsterdam UMC have developed a new diagnostic test that can quickly and accurately diagnose bacterial meningitis. The test measures the CRP protein in cerebrospinal fluid, a protein that is already often tested in blood to detect bacterial infections. Research shows that elevated CRP in cerebrospinal fluid is a very reliable indicator of bacterial meningitis. Currently it often takes a long time before meningitis is diagnosed, which delays the start of adequate treatment. The study is published today in The Lancet Regional Health Europe.
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Detecting lung cancer four months earlier at the GP using artificial intelligence GPs may soon be able to identify patients with an increased risk of lung cancer up to 4 months earlier than is currently the case. The GP should be able to simply identify patients during a consultation with an algorithm created by researchers at Amsterdam UMC based on the data of more than half a million patients. The results of the study were published today in the British Journal of General Practice
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Surgery after a stroke due to carotid artery stenosis is no longer necessary for a large group of patients European research led by University College London (UCL), together with Amsterdam UMC and the University of Basel shows that a significant proportion of patients who suffer a stroke due to carotid artery narrowing can be treated with medication only. A risky carotid artery operation, currently still the standard treatment for many patients, may then no longer be necessary for this group of patients. This research, published today in the Lancet Neurology, may lead to the global guidelines for the treatment of these patients being adjusted.
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Global first: MRI used in treatment of complex cardiac arrhythmia Amsterdam UMC has used an interventional MRI (iMRI) scanner to successfully perform a cardiac ablation in a patient with ventricular arrhythmia, for the first time. Typically used for diagnosis, MRI is increasingly used during cardiac interventional procedures as it offers more visual insight. This global first sets a major step toward the use of iMRI as alternative treatment option for these arrhythmias.
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Dietary shift after migration increases cardiovascular risk by altering the composition of an individual's gut microbiome An Amsterdam UMC-led study has found that migrants, this case from West Africa to Europe, experience a ‘clear change’ in their microbiome composition as compared to their non-migrant peers in West Africa, which expose them to an increase of cardiovascular disease. These peer-reviewed findings are published today in the journal Gut Microbes demonstrating that participants who lost specific groups of microbes or acquired specific new groups of microbes had higher rates of cardiovascular risk factors such as hypertension, diabetes, obesity, and poor kidney function.
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Intravenous anaesthesia greatly reduces CO₂ emissions: comparable to annual emissions of Denmark What if you could save 98 percent of CO₂ emissions during surgery with just one change? And what if that change also improved patient recovery and saved costs? Then you's probably want to implement that adjustment as quickly as possible, preferably worldwide. That is the mission of Amsterdam UMC anaesthesiologist Niek Sperna Weiland: “Our relatively small professional group can ultimately achieve a worldwide reduction in CO₂ emissions that is as large as the annual emissions of all of Denmark.” The adjustment in question: intravenous anaesthesia, instead of an anaesthetic gas.
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New insights into how cancer evades the immune system Research into immunotherapy against cancer typically focuses on better recognition of cancer cells by the body's own immune system. Researchers at Amsterdam UMC and Moffitt Cancer Center have taken a different approach. They investigated how cancer affects the energy management of a patient’s T cells and showed for the first time that contact with chronic lymphocytic leukaemia (CLL) cells leads to a serious energy crisis in these cells. These findings are published today in Cellular & Molecular Immunology, building on a publication earlier this month in Blood Advances.
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Tocolytic drugs that inhibit contractions after 30 weeks of pregnancy has no effect on a baby's health The use of tocolytic drugs in cases of threatened premature birth after 30 weeks of pregnancy does not improve the baby’s health. “There was no benefit but also no harm done," says Amsterdam UMC PhD-student Larissa van der Windt. The results of the largest study concerning the effectiveness of tocolytic drugs on the health of babies, led by Amsterdam UMC, were published today in The Lancet.
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