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                                New medication sinus thrombosis just as safe but more patient-friendly Patients affected by sinus thrombosis are treated with blood thinners. Traditionally, these patients are prescribed vitamin K antagonists (VKAs). In order to give the correct dosage, regular check-ups at the thrombosis service are necessary. A global study, coordinated by Amsterdam UMC, now shows that new medication, direct oral anticoagulants (DOACs), are equally safe and effective. The study was published today in The Lancet Neurology.
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                                A new gene identified in the search for a therapy to treat malignant cardiac arrhythmia Cardiac arrhythmias affect millions across the world and are responsible for around 15% of all deaths worldwide. Currently there are multiple treatment options, ranging from life-long medication to invasive surgical procedures. Research from Amsterdam UMC and Johns Hopkins University, published today in the European Heart Journal, sets another important step in the hunt for a one-off gene therapy that could improve heart function and protect against arrhythmias.
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                                'There is a lot of hunger for knowledge among policymakers' Hoogleraar Vroege ontwikkeling en gezondheid Tessa Roseboom houdt zich al jaren bezig met de vraag hoe mensen gevormd worden door de omgeving waarin ze opgroeien, onder andere met het Hongerwinteronderzoek. De kennis die zij en haar collega-wetenschappers verzamelen, draagt ze actief uit. Dit kan beleidsmakers aan inzichten helpen om het leven van burgers, nu en in de toekomst, te verbeteren.
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                                Amsterdam UMC leads global research to stop Crohn's disease Crohn's disease is advancing rapidly in the Western world. The international consortium INTERCEPT, led by Amsterdam UMC, will investigate how this disease can be detected and stopped at an early stage. "If this succeeds, the health benefits for society will be enormous," says Geert D'Haens, professor of Inflammatory Bowel Diseases and head of the department of gastroenterology and liver disease at Amsterdam UMC. To carry out this investigation, the consortium will receive a European grant of 37.5 million euros.
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                                Burning away liver metastases in patients with colorectal cancer offers faster recovery and fewer complications Heating (thermal ablation) of small metastases in the liver in patients with colon cancer results in fewer complications and allows the patient to return home faster, all while providing a similar chance of survival as surgically removing the tumours. These are the headline results of the COLLISION trail, carried out by Amsterdam UMC and the Dutch Colorectal Cancer Group, published today in The Lancet Oncology.
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                                New Parkinson's treatment method in which the brain itself controls implanted electrodes In deep brain stimulation (DBS), implanted electrodes continuously deliver shocks, pulses, to the brains of patients with Parkinson's disease or neurological or psychiatric disorders. Usually the symptoms, such as trembling, are reduced as a result. Sometimes, however, the effect is limited, or the treatment causes side effects. Adaptive DBS (aDBS) can offer a solution by only giving pulses when the patient's brain itself asks for them. Amsterdam UMC neurologist Martijn Beudel has been researching aDBS for over 10 years. On 13 January, the first patient in the world was treated 'tailor-made' with this method outside of study.
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                                Working together against rare diseases To ensure that patients with rare diseases can count on the right care everywhere in Europe, the European Commission created the Reference Networks in 2017. These ERNs are now also increasingly active in research and education and have achieved a central position in the academic world. Also at Amsterdam UMC, where 2 of the 24 networks are coordinated.
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                                Genomic Study Reveals Causal Link Between PTSD and Cardiovascular Disease, Offering New Insights for Prevention and Treatment Those with posttraumatic stress disorder (PTSD) are at increased risk of cardiovascular diseases. Why this is, remains unknown. Researchers from Amsterdam UMC and Yale University analysed the genomic data of more than a million individuals and found a shared genetic predisposition for both PTSD and cardiovascular disease. Further, they found strong evidence that PTSD causally increases the risk of cardiovascular diseases. This study is published today in Translational Psychiatry.
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                                Hormone therapy reshapes the skeleton in transgender individuals who previously blocked puberty Skeletal size may be altered by gender-affirming hormone therapy only if puberty has also been suppressed during adolescence, according to research presented at the 62nd Annual European Society for Paediatric Endocrinology Meeting in Liverpool. The findings from this research, carried out by Amsterdam UMC, not only help researchers further understand the roles sex hormones play on the skeleton but may also improve counselling on gender-affirming treatment in transgender individuals.
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