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New Parkinson's treatment method in which the brain itself controls implanted electrodes In deep brain stimulation (DBS), implanted electrodes continuously deliver shocks, pulses, to the brains of patients with Parkinson's disease or neurological or psychiatric disorders. Usually the symptoms, such as trembling, are reduced as a result. Sometimes, however, the effect is limited, or the treatment causes side effects. Adaptive DBS (aDBS) can offer a solution by only giving pulses when the patient's brain itself asks for them. Amsterdam UMC neurologist Martijn Beudel has been researching aDBS for over 10 years. On 13 January, the first patient in the world was treated 'tailor-made' with this method outside of study.
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Working together against rare diseases To ensure that patients with rare diseases can count on the right care everywhere in Europe, the European Commission created the Reference Networks in 2017. These ERNs are now also increasingly active in research and education and have achieved a central position in the academic world. Also at Amsterdam UMC, where 2 of the 24 networks are coordinated.
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Genomic Study Reveals Causal Link Between PTSD and Cardiovascular Disease, Offering New Insights for Prevention and Treatment Those with posttraumatic stress disorder (PTSD) are at increased risk of cardiovascular diseases. Why this is, remains unknown. Researchers from Amsterdam UMC and Yale University analysed the genomic data of more than a million individuals and found a shared genetic predisposition for both PTSD and cardiovascular disease. Further, they found strong evidence that PTSD causally increases the risk of cardiovascular diseases. This study is published today in Translational Psychiatry.
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Hormone therapy reshapes the skeleton in transgender individuals who previously blocked puberty Skeletal size may be altered by gender-affirming hormone therapy only if puberty has also been suppressed during adolescence, according to research presented at the 62nd Annual European Society for Paediatric Endocrinology Meeting in Liverpool. The findings from this research, carried out by Amsterdam UMC, not only help researchers further understand the roles sex hormones play on the skeleton but may also improve counselling on gender-affirming treatment in transgender individuals.
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Study quantifies impact of rapid first shock after cardiac arrest It is well known that acting quickly in the event of a cardiac arrest is important, but what does a quick initial shock with a defibrillator mean exactly for patients' chances of survival? Researchers from Amsterdam UMC analysed the data of 3723 patients who had a cardiac arrest outside the hospital and concluded that for the first shock, every minute reduces the chance of survival by 6%. The results of this research were published in the journal Circulation.
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Phase Two results with CRISPR-Cas9 gene editing support further development as treatment for hereditary angioedema A single treatment with, a CRISPR-Cas9 based gene editing therapy, is enough to replace the daily medication of patients with hereditary angioedema (HAE), a condition characterized by severe, painful and sudden onset of swelling, sometimes resulting in death. Confirming the findings published earlier this year from researchers from Amsterdam UMC, the University of Auckland and Cambridge University Hospitals NHS Foundation Trust. This phase two study is published today in the New England Journal of Medicine and presented at American College of Allergy, Asthma & Immunology's annual congress on the 26th of October.
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Predicting epilepsy after rare stroke Researchers from 15 countries, led by Amsterdam UMC, have developed a way to predict which patients are at risk of epilepsy after a cerebral venous sinus thrombosis (CVT). CVT is a type of stroke that typically affects women between the ages of 20 and 50. The prediction model is now available worldwide free of charge and research it is based on is published in JAMA Neurology.
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About the Amsterdam UMC Doctoral School The Amsterdam UMC Doctoral School is to support you during your PhD trajectory and strives to be a well-known and appreciated partner for PhD candidates and their supervisors.
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PhD graduation Timeline and information of your PhD graduation at Amsterdam UMC.
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