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A computerised decision support system significantly reduces high-risk drug combinations in Intensive Care patients A recent multicentre study led by Amsterdam UMC and conducted in nine Dutch Intensive Care Units (ICUs) has shown that tailoring a computerised decision support system (CDSS) to the ICU environment significantly reduced the number of high-risk drug combinations administered to ICU patients. It also improved monitoring ICU patients when avoiding such combinations was not possible, and reduced the length of patients’ stay in the ICU. This study is published today in The Lancet.
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Priming, Shaping and Polishing: In search of a HIV Vaccine Worldwide, an estimated, 40 million people live with HIV. Two-thirds of this group on the African continent. In 2022, more than 600,000 people died from HIV-related causes and more than 1.3 million were infected. There is no vaccine against the world's second most deadly infection, after TB. Thanks to a grant from the Bill & Melinda Gates Foundation, Amsterdam UMC's Rogier Sanders leads a project that aims to develop the first effective HIV vaccine.
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Tackling the effect of climate change on diarrheal diseases Diarrhoea is, globally, the second largest cause of death for children under 5. Contributing to more than 500,000 deaths, only pneumonia kills more children each year. Climate change, driving increased flooding and droughts, threatens the fragile progress made in reducing the burden of diarrheal disease over the past decades. Together with the Amsterdam Institute of Global Health and Development, Amsterdam UMC is set to lead a global consortium in the hunt for improved interventions.
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Tiredness experienced by Long-COVID patients has a physical cause Researchers from Amsterdam UMC and Vrije Universiteit Amsterdam (VU) have discovered that the persistent fatigue in patients with long-COVID has a biological cause, namely mitochondria in muscle cells that produce less energy than in healthy patients. The results of the study were published today in Nature Communications.
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Reinventing the wheel with 'organoids' Organoids are complex, three-dimensional cell cultures, which are gaining an increasingly important place in medical research. To prevent all research groups from reinventing the same wheel, Amsterdam UMC has now set up a special centre to bundle the work on organoids: the ORCAU.
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Amsterdam UMC to use AI to increase the accessibility of medical imaging technology The demand for acquiring and interpreting medical images is increasing faster than number of medical experts required to operate the medical imaging device and interpret their output. This is leading to an increase in the expert workload and extending waiting lists. An Amsterdam UMC-led consortium wants to tackle this problem by making imaging technology more accessible. With the help of artificial intelligence, they want to enable less specialized experts to acquire and analyse medical images. To support them in this goal, the Dutch Research Council (NWO) has awarded the AI4AI project a grant of 6.1 million euros
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Christmas turkey stuck in your throat? Don't reach for the cola Cola. A drink forever associated with the Christmas season. And also, for many, a liquid that can help clear a blocked oesophagus. Something that may be a bit more likely at this time of year. However, research from Amsterdam UMC, published today in the BMJ Christmas Issue, shows that this is not worth wasting the sugary stuff.
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Simulating Stroke Treatments with a Digital Twin It sounds like something from a science fiction film. Assessing the best treatment for a patient with an ischemic stroke or cerebral haemorrhage by performing the procedure on their digital twin. If it's up to researchers at Amsterdam UMC, this will be reality in six years. They've received a Horizon grant worth 10 million euros from the European Commission to lead 19 partners in making this a reality.
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In search of a cure for HIV for the group that are hit the hardest A universal solution to the HIV epidemic, regardless of what type of virus the patient has. That is the ambition of Dutch and African researchers in the SPIRAL-project. They recently received a grant of more than 6 million euros from the Netherlands Organisation for Scientific Research (NWO) and the AidsFonds.
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Measuring tumours quickly and precisely thanks to AI The CAESAR research group at Amsterdam UMC have developed an AI tool that automatically shows liver tumours on CT scans of patients with colon cancer that has spread to the liver, giving doctors quick insight into the size of the tumours. The fact that the tool is now being researched in the doctor's daily practice is good news, as many AI tools are stuck in the development phase. Researcher Michiel Zeeuw explains how this software came about.
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