Amsterdam Movement Sciences

Dana Graves is hoogleraar parodontitis en auteur van meer dan 200 artikelen in o.a. PNAS, Science en Journal of Experintal Medicine.

Abstract: Microbial dysbiosis induced by the application of P gingivalis and F nucleatum reproducibly induces periodontitis. Periodontal ligament fibroblasts and osteocytes play a key role in the disease process as lineage-specific inactivation of NF-kB in these cells prevents dysbiosis-induced periodontal bone loss. Immature mesenchymal cells that express Prx1 play key roles in inflammation that is context dependent. In adult bone and gingiva, they are needed to resolve inflammation that allows healing to occur normally. However, in early postnatal skin development, NF-kB plays a key role in these cells by suppressing chemokine expression and preventing the formation of inflammatory lesions.