Amsterdam Gastroenterology Endocrinology Metabolism

The AGEM research institute has a seminar series in the Amsterdam UMC, location AMC, focused on metabolism; the Tager Lecture, called after Professor Joseph Tager. Joseph Tager made important contributions to Fabry, Pompe and Gaucher disease and had a major impact on our understanding of peroxisomal diseases. He was chairman of the Biochemistry Department at the University of Amsterdam (1980-1991).
The Tager Lecture series is organized by AGEM PI’s Riekelt Houtkooper, Susanne La Fleur, Stan van de Graaf and Noam Zelcer.
Suggestions for future speakers for the Tager lecture are always welcome.
AGEM Tager Lecture: Prof. dr. Herzig:
“Coordination of systemic metabolism by inter-cellular signaling”
Systemic energy homeostasis is determined by the intricate interplay between different organ compartments, including the central nervous system, skeletal muscle, liver as well as white and brown adipose tissue (WAT/BAT). Indeed, the coordinated adaptation of metabolic pathways in different tissues to changing environmental cues is critical for systemic metabolic health. However, integrative molecular checkpoints in inter-tissue communication and/or coordination still remain largely unknown. Here, I will discuss the recent identification of novel inter-cellular cross-talk mechanism in hepatic and systemic energy homeostasis.