Amsterdam Gastroenterology Endocrinology Metabolism

Hernia Endoscopic oR opeN repair In chIldren Analysis (HERNIIA-2) The aim of the HERNIIA-2 study, is to investigate the most (cost-) effective way to repair a groin hernia in children between 0-16 years.

Clinical, diagnostic and genetic aspects of central congenital hypothyroidism (CH) The Dutch neonatal screening program allows for the detection of congenital central hypothyroidism (CCeH) and facilitated identification of patients with CCeH over the past decades.

Precision use of Antibiotics in Infected NecrOtizing Pancreatis (PIANO) The aim of this study is to assess whether a multifaceted approach based on antibiotic stewardship principles results in more appropriate use of antibiotics in necrotizing pancreatitis.

Aetiology of renal and urinary tract anomalies defines Diagnostic Efficacy and Clinical Outcome (ArtDECO) The ArtDECO study is a national study on the cause and prognosis of congenital anomalies of the kidney and urinary tract.

Nationwide implementation study of an evidence-based management algorithm Current care in Dutch chronic pancreatitis proved not to be in accordance with the European Guidelines which may indicate suboptimal care.

Best treatment options for complex appendicitis in children (CAPP-study) The CAPP study is a national prospective cohort study comparing different treatments for children with complex appendicitis.

Towards individual prognostication in Classical Galactosemia Classical Galactosemia (CG) is an inborn error of galactose metabolism. In spite of early diagnosis and dietary treatment many patients develop neurological and cognitive complications.

Antibiotics versus Primary Appendectomy in Children with simple appendicitis (APAC-trial) The hypothesis of the APAC trial is that antibiotic treatment in children with simple appendicitis is non-inferior to surgery.

Worldwide study on neuroendocrine tumors of the appendix in children (Appendix NET-study) The purpose of this project is to investigate whether the comprehensive second operation on the colon is necessary in children in the high-risk tumor group

Gluten-related Neurological Disorders Various neurodegenerative disorders have been associated with an inappropriate reaction to dietary gluten intake. The underlying neuropathological mechanism is still unclear.

Targeting hepatic bile salt uptake to treat cholestasis or the metabolic syndrome In this project we aim to understand the role of bile acids (and its dynamics) in energy, fat and glucose homeostasis, and in inflammation.

From disease transcriptome to drug discovery Researchers at the Laboratory Genetic Metabolic Disease are looking at drug development in a different way. Their computational pipelines are greatly accelerating the drug discovery process.