Both diabetes and hypertension represent major threats to population health and health care in the Netherlands, with over 1 million people affected by diabetes alone. This prevalence is expected to increase by ~30 percent in the next 15 years. As obesity prevalence is expected to double in this period, type 2 diabetes mellitus, the metabolic syndrome (and their co-morbidities will profoundly affect our health and economy.
Both conditions share epidemiological features (like premature cardiovascular diseases of ageing), pathophysiological mechanisms (including systemic microvascular dysfunction) and clinically important cardiovascular complications.
- The pathogenesis of type 2 diabetes mellitus and diabetes-related complications and comorbidities
- Novel therapies for type 2 diabetes mellitus
- Cardiovascular disease driven by hypertension, obesity, type 2 diabetes and/or chronic kidney disease
- To unravel the pathogenesis of hypertension and its link to cardiovascular disease
- Novel hypertension therapies
- Links between metabolic, cardiovascular (including heart failure), and kidney disease through impaired microvascular function
Focus
- Biobank studies and computational modeling
- Detailed human metabolic and hemodynamic phenotyping at clinical trial units including assessment of insulin sensitivity, beta-cell function and tissue based data obtained from biopsies
- Clinical and experimental models (e.g. mice, co-cultures, subjects at risk) for microvascular dysfunction
- Fecal microbiota transplantation studies
- Studies investigating sodium and potassium homeostasis in people with chronic kidney disease
Unique research expertise
Aim
Our overall goal is to lead in translational population-based, clinical and basic research focusing on diabetes, hemodynamic and metabolic derangements that lead to cardiovascular and kidney complications.
Program Leaders
Young ACS
Program members
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Aart NederveenPI PROF.DR.IR.
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Abel ThijsDR.
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Abraham Stijn Meijnikman
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Albert WiegmanPI DR.
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Albertus KooterDRS.
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Aldo Grefhorst
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Alessandra TammaroPI PhD
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Alinda SchimmelBEng BSc
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Aline Fenneman
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Amber KornMSC.
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Angélique de ManPI DR.
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Angelique ScantleberyMSc
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Anne Myrthe van Vliet
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Annette MollPI PROF.DR.
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Annick HartstraMD
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Armand GirbesPI PROF.DR.
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Azam NurmohamedDR.
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Barbara HuttenPI DR.
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Barbara Verhaar
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Benedikt PreckelPI Prof. MA MD PhD
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Bert GroenProf. PhD
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Bram HulstMD
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Bram Veldman
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Brigitta van JaarsveldPI DR.
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Britt WeverDRS.
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Camiel de Roij van Zuijdewijndr.
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Carolien BulteDR.
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Caroline de VriesPI PROF.DR.
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Cengiz Callender
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Charles AgyemangPI Prof. PhD
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Chun-Xia YiPI DR.
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Dana YumaniDR.
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Daniël van RaaltePI PROF.
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Daniela Stols-GoncalvesDRS.
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Daniko Sindhunata
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Denise VeeloPI MD PhD
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Dick MarkhorstDR.
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Dink LegemateProf. PhD
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Eduard van der Vossen
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Eefje Belt
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Elena RampanelliPI PhD
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Eric Moll van CharantePI Prof. MD PhD
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Erik SernéPI DR.
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Etto EringaPI DR.
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Eveline BruinstroopPI DRS.
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Fabrice MartensPROF.DR.
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Femke RuttersPI DR. Associate professor, Principal Investigator and Principal Educator
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Florine Westerbeke
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Fred VazPI PhD
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Ganapathy van SamkarMD
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Gerie GlasDRS.
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Han Jiao
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Henning HermannsDR.
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Hilde HerremaPI PhD
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Ilaria Micallo
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Ilias AttayeMD
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Ilona DekkersDR.
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Ingeborg KlaassenPI PhD
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Irene van ValkengoedPI PhD
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Jacqueline Hoozemans
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Jithsa Monte
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Johanna Hakonen
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Johannes LevelsPhD
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Joline BeulensPI PROF.DR.IR.
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Jonathan Overeem
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Joost van den AardwegProf.
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Joris RoelofsPI PROF.DR.
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Juan Miguel Téllez Garcia
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Julia Witjes
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Karien StronksPI PROF.DR.
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Koen WortelboerMSc
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Lars SnelDRS.
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Liffert VogtPI PROF.DR.
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Lily JakuljDR.
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Lonneke van VughtDR.
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Lot Mosterd
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Lotje van Ruiten
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Lotte de BoerDR.
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Lucas Bresser
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Maaike Winkelmeijer
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Maarten SoetersPI MD PhD
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Marc van HeerdeDR.
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Marc VervloetPROF.DR.
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Marcus SchultzPI Professor PROF.DR.
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Mariah Daal
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Marieke BlomPhD
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Mariëlle Bruins
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Mark DavidsPhD
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Mark KramerPI PROF.DR.
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Marlene van den BergBEng
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Max NieuwdorpPI PROF.DR.
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Michel van WeeghelMSc PhD
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Michiel van Baar
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Micky Karsten
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Mijra Koning
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Milan RidderikhofDR.
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Mirjam LangeveldPI DR.
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Mirjam van WeissenbruchPROF.DR.
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Mirthe MuilwijkPhD.
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Miryam ObdeijnDR.
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Moyan Liu
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Muriel GrootemanPI DR.
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Nam Bui
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Nienke van Olst
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Noam ZelcerPI Prof. PhD
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Noelle Bakker
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Nordin HanssenPI
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Omrum AydinMD DRS.
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Onno HolleboomPI DR.
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Oren LapidDR.
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Paola Serrano Martinez
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Patrick de Jonge
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Patrick ThoralDRS.
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Peter HarmsPhD
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Petra EldersPI PROF.DR.
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Pieter ter WeePI PROF.DR.
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Pieter ZwanenburgBSc
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Prabath NanayakkaraPI PROF.DR.
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Reinoldus GemkePI PROF.DR.
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Richard IJzermanPI DRS.
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Riekelt HoutkooperPI Prof. PhD
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Rik Olde EngberinkPI PhD
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Rob van HulstPROF.DR.
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Roelof OttenhoffBEng
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Rogier ImminkMD PhD
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Rogier SchadeDR.
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Romain Meer
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Roosje RoelantsMD
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Rosa WoudaMSc
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Rosalie ScholtesDRS.
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S HavikMEng
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Sabine van Oort
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Sabrine Chaara
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Samantha SchipperMSC.
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Sandra StapelDR.
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Sanedy Simon
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Sanne LithMSC.
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Sean Platton
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Sebastian HendrixMSc
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Shaynah Wanga
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Signe Nielsen
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Sophie Veldhuijzen van ZantenDRS.
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Stan Driessen
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Stephan LoerPI PROF.DR.
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Susanne PicardiMD PhD
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Suzanne van WouwMSc
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Thei Steenvoorden
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Torsten Scheithauer
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Victor GerdesPI MD PhD
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Vincent WekkerMD
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Wafa Karar
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Wolfgang SchlackProf. MD PhD
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Yvo SmuldersPI PROF.DR.