PI
Specialization
Cardiology, Cardiogenetics
Focus of research
Clinical Research:
- Projects:
- Pathophysiology of inherited and acquired cardiac arrhythmias, e.g., Brugada syndrome, Long QT syndrome, drug-induced arrhythmias
- Genetic basis and clinical determinants of inherited heart disease, in particular, primary arrhythmia syndromes, sudden cardiac death, and cardiomyopathies
- Electrophysiological and structural remodeling in right ventricular failure
- Genetic basis of congenital structural heart disease
-
- Methods:
- Noninvasive cardiac electrophysiology: body surface mapping
- Invasive cardiac electrophysiology: electrophysiologic study, epicardial mapping during cardiac surgery
- Imaging: echocardiography
-
Basic Research:
- Projects:
- Molecular basis of right ventricular failure
- Ion channel remodeling in congestive heart failure
- Biophysical characterization of variant ion channels in primary arrhythmia syndromes
- Development of a bio-engineered cardiac pacemaker
-
- Methods:
- Patch-clamp studies of isolated myocytes and transfected cell cultures
- Electrical and optical activation mapping
- Viral transduction of cultured myocytes
- Imaging: echocardiography
-