Grand Rounds in Digestive Diseases
From the origins of colorectal cancer, to duodenal resurfacing for the treatment of diabetes, to spatial omics to decipher the role of macrophages in liver disease. These are just a few examples of the series of lectures organized by the Department of Gastroenterology & Hepatology, entitled ‘Grand Rounds in Digestive Diseases’.
In monthly Thursday morning sessions, top-level scientists from the Amsterdam UMC and beyond provide a broad audience with an overview of the recent scientific advances in their research field. In addition to purely scientific Gastroenterology & Hepatology-related presentations, sometimes more general topics are covered.
These series of lectures have been initiated by Prof. Geert D’Haens and Dr. Joep Grootjans from the department of Gastroenterology & Hepatology. Topics are selected by a steering committee which includes clinical and basic scientists from the departments of Surgery, Paediatrics, Radiology, Pathology and the Tytgat Institute. The Grand Rounds are hosted both on-site at location VUmc (Auditorium, O2-building) and online via zoom Thursday mornings from 8.00AM to 8.45AM.
2025
30 January 2025
Schalk van der Merwe
From Palliation to Prolongation: Transforming Biliary Drainage in Cancer Care
27 February 2025
Rinse Weersma
The gut microbiome in health and disease
27 March 2025
Daniel Keszthelyi
Rediscovering the Wanderer – The Therapeutic Potential of Vagus Nerve Stimulation
17 April 2025
Marco Bruno
Surveillance of high-risk individuals for developing pancreatic cancer
2024
29 February 2024
Barbara Bastiaansen
New horizons in the endoscopic treatment of early colorectal cancer
28 March 2024
Jacco van Rhenen
Intravital microscopy of GI cancer
25 April 2024
Gijs van den Brink
Facing fearful odds: turning molecules into medicines
30 May 2024
Lissy de Ridder
Investigator Initiated Research in the paediatric IBD field
27 June 2024
Guus van Dongen
Fibrobodies and Fibrobody-Drug Conjugates: a vision for diagnosis and therapy of fibrosis
3 October 2024
Myriam Chalabi
Immunotherapy for colorectal cancer: are we there yet?
24 October 2024
Mariëtte van den Hoven
Ethical dilemmas in Artificial Intelligence (AI)
28 November 2024
Geert Litjens
AI for GI: possibilities of computational pathology?
19 December 2024
Philip Chiu
Advancing Third Space Endoscopy – From Endoluminal to Full Thickness Resection
2023
Joep Bartelsman
Four decades of gastrointestinal endoscopy in Amsterdam” Memorial Lecture for Prof Kees Huibregtse
26 January 2023
Max Nieuwdorp
The impact of microbiome and microbiome modulation on systemic diseases
9 February 2023
Regina Beets-Tan
Modern imaging of Colorectal cancer
23 February 2023
Marca Wauben
The unknown messengers of the body: extracellular vesicles
9 March 2023
Saskia Peerdeman
Data-driven and digital learning, future perspectives
6 April 2023
Bas Oldenburg
Colitis-associated neoplasia
20 April 2023
Sven Francque
Vascular alterations in NASH pathophysiology
1 June 2023
Cyriel Ponsioen
PSC, an orphan groing up
15 June 2023
Joep Derickx
Intestinal anastomotic healing and leakage
29 June 2023
James Kinross
iEndoscope – towards real time precision metabolic phenotyping in the operating room
9 September 2023
Robert Porte
Why bile ducts continue to be the Achilles’ heel of liver transplantation and what we can do about it
21 September 2023
Johan van Limbergen
Optimizing nutritional therapy of IBD
5 October 2023
Joost Drenth
Angiodysplasieën, from start to finish
19 October 2023
Roos Pouw
Unethical or unprecedented: novel management strategies for high-risk esophageal adenocarcinoma
2 November 2023
Geert Kazemier
Gastrointestinal Cancer Care: Connecting the Dots
16 November 2023
Anne Griffiths
Revisiting treatment algorithms in paediatric Crohn’s disease
30 November 2023
Gerd Bouma
Celiac disease
14 December 2023
Jan Paul Medema
A view to a kill; the balance between life and death in the intestine
2022
Prof. Marcel Levi
Is there any impact of differences in health care systems on outcome?
27 January 2022
Prof. Evelien Dekker
Population screening for colorectal cancer: strengths, weaknesses, opportunities and threats
10 February 2022
Prof. Jaap Stoker
Novel MR imaging techniques for inflammatory and motility disorders of the small bowel
10 March 2022
Prof. Wouter de Jonge
The gut-brain axis-how the nervous system controls inflammation
24 March 2022
Dr. Charlotte Scott
DeLIVERing an atlas of hepatic macrophage populations across species and disease
7 April 2022
Prof. Geert d’Haens
Breaking the therapeutic ceiling in Crohn’s disease
21 April 2022
Dr. Rutger-Jan Swijnenburg
Image-Guided Precision Robotic Liver Surgery
12 May 2022
Prof. Jaap Bonjer
Going DUTCH; Digital United Training Centres for Healthcare
2 June 2022
Prof. Joanne Verheij
Clinical relevance of the molecular subclassification of liver tumors
16 June 2022
Dr. Nanne de Boer & Dr. Tim de Meij
Volatile biomarkers in gastroenterology
30 June 2022
Prof. Paul Fockens
Treating acute pancreatitis is teamwork!
8 September 2022
Prof. Willem Bemelman
More than 25 years of IBD Surgery: lessons learned
22 September 2022
Prof. Ronald Oude Elferink
‘The seven year Itch’
6 October 2022
Prof. Marc Besselink
Thrilling progress in surgical management of pancreatic cancer
3 November 2022
Prof. Guy Boeckxstaens
Mast cells as new target for the treatment of abdominal pain
10 November 2022
Prof. Arjan Bredenoord
Epidemic of a new disease: eosinophilic esophagitis
1 December 2022
Prof. Ernst Kuipers, Dutch Health Care Minister
College Tour Edition
15 December 2022
Prof. Marlies Schijven
The black Box in operation room: a treat or blessing?
EKZ Grand Rounds & Inspirational Sessions
At the end of 2023, the science committee of the Emma Children's Hospital was established in order to organize the monthly Grand Rounds in Pediatric Research. These Grand Rounds provide a platform for the wonderful scientific projects and developments in and around the Emma Children's Hospital, as well as increase cooperation and visibility of (young) researchers. These Grand Rounds are open to all employees of the Amsterdam UMC. Especially the presence of the researchers, staff physicians and physician assistants at the Emma Children's Hospital is highly anticipated.
The EKZ Science Committee also organizes Inspirational Speaker Sessions on Pediatric Research. These sessions are for EKZ researchers, young and older, and all interested parties in Amsterdam UMC are welcome!
Organized by the EKZ Research Committee: ekzwetenschapscommissie@amsterdamumc.nl
Titel
Thursday January 9, 2025
Grand Rounds: Jolanda
PhD Spotlight
Thursday February 13, 2025
Grand Rounds: Aranka Wesemael & Rimke de Kroon
Festival of mistakes
Thursday February 27, 2025
Inspirational Speaker
Fasting in Islam and Christianity
Thursday March 13, 2025
Grand Rounds: Dana Yumani & Sjanna Besteman
Inclusive Education
Thursday April 10, 2025
Grand Rounds: Jolanda and Jenneke
PhD Spotlight
Thursday May 8, 2025
Grand Rounds: Wouter Hehenkamp
Sustainability in healthcare
Thursday June 12, 2025
Grand Rounds: Clara van Karnebeek
Serious Request
2024
Thursday January 11, 2024
Grand Rounds: Charles Agyemang
Cardiometabolic disease burden in migrants in Europe – Lessons from the RODAM study
Thursday February 15, 2024
Inspirational speaker: Joep Derikx
My career as pediatric surgeon
Thursday March 14, 2024
Grand Rounds: BrainStormzy
Brainstorming session about the pilars of the EKZ Research Committee
Thursday April 18, 2024
Inspirational speaker: Ruud van Leuteren
Technical physician with a focus on respiratory support and cardiorespiratory monitoring
Thursday April 25, 2024
Grand Rounds: Arne Popma
Levensloop mentale gezondheid: van de hoek van de straat tot het Emma Kinderziekenhuis / Mental health life course: from the street corner to the Emma Children's Hospital
Thursday May 16, 2024
Grand Rounds: Rianne Teeuw
De ‘Amsterdamse’ Sociale Pediatrie / The 'Amsterdam' Social Pediatrics
Thursday June 20, 2024
Grand Rounds: Simone Sanna-Cherchi
Genetic dissection of pediatric kidney diseases
Thursday June 27, 2024
Inspirational speaker: Mariken Gruppen
Een leven lang leren!/Lifelong learning!
Thursday September 12, 2024
Grand Rounds: PhD Spotlight
Thursday September 26, 2024
Inspirational speaker: Haunted house
Thursday October 10, 2024
Grand Rounds: Karen Kruijthof & Willem de Vries
Opportunities and challenges – perspectives on tomorrow's care. Future of healthcare, Future of pediatrics
Thursday November 14, 2024
Grand Rounds: Lidewij Henneman
Patient perspective in screening around pregnancy and childbirth.
Thursday December 12, 2024
Grand Rounds: Wieger Voskuijl
Global Child Health
2023
On Thursday December 14th, the new EKZ Grand Rounds in Pediatric Research seminar series kicked off with its first lecture!
Thursday December 14, 2023
Grand Rounds: Marlies Schijven
You’re braver than you believe, stronger than you seem and smarter than you think; when the going gets tough
ImmunoMetNet series
After a couple of successful annual ImmunoMetNet meetings and many online seminars, the organizers decided to start a local ImmunoMetNet Amsterdam UMC series where “young” Amsterdam UMC researchers from distinct disciplines and research institutes get the chance to present immunometabolism-related work. As such, ImmunoMetNet AMS will create a new network between at least AGEM, CCA, ACS, AII and Neuroscience. Hereby, we aim to share expertise, tools and samples across the borders of the distinct Amsterdam UMC research institutes with immunometabolism as the unifying factor.
This comes down to low-key interactive meetings with immunometabolism-focused presentations by “young” Amsterdam UMC researchers from distinct disciplines across at least five Amsterdam UMC research institutes. Drinks and snacks are supplied to fuel ImmunoMet-Networking.
Keep an eye on www.immunometnet.com and the @immunometnet X/Twitter profile or reach out to immunometnet@amsterdamumc.nl for more information on future ImmunoMetNet events!
2025
Tuesday January 21, 2025
Amsterdam UMC, location VUmc, O|2 building
The local ImmunoMetNet meeting was well-attended with +30 attendees and there were 4 interesting talks by junior researchers from distinct research institutes.
- Sabrina van der Dussen-Pollastro(Postdoc in the group of Marieke van Ham, Sanquin) presented on how she is applying scRNA-seq to dissect metabolic changes during B cell differentiation.
- Demi Both(PhD student in the lab of Eric Eldering with Helga Simon Molas (AMC)) presented less metabolic but very interesting work on translation regulation in cancer
- Christine van Linge(PhD in the lab of Alex de Vos and Tom van der Poll, AMC) presented her PhD work on immunometabolic pathways in human alveolar macrophages
- Serhii Chornyi (Postdoc in the lab of Gijs Kooij, VUmc) showed lipidomics data revealing that macrophages produce specific lipid mediators during pneumococcal meningitis
2024
Tuesday September 24, 2024
Amsterdam UMC, location AMC, Costerzaal
On the 24th September, the last ImmunoMetNet AUMC Seminar of 2024 was held at Costerzaal AMC with around 30 attendants and four junior researchers as speakers.
- Yumna Butt, PhD student in the group of Iosifina Foskolou at Sanquin, shared their data on the role of m6A RNA metabolism on T cells.
- Nina Mezgec Mrzlikar, PhD student in the group of Joep Grootjans at AMC/VUmc, gave a talk on metabolic profiling of human peritoneal macrophages, with the specific aim of finding novel treatment targets for peritoneal metastasized cancer.
- Beatriz Fernandes Corte-Real, postdoc in the group of Jan Van den Bossche at VUmc, presented the Metabocode, which consists of the characterization and modulation of the metabolism of tumor-associated macrophages.
- Daan Kloosterman, PhD in the group of Leila Akkari at NKI, shared a story on macrophage-mediated recycling of cholesterol-rich myelin debris, which fuels brain cancer malignancy.
The session was followed by casual discussion over bites and drinks provided by AGEM.
Tuesday January 30, 2024
Amsterdam UMC, location AMC, Costerzaal
The first meeting of ImmunoMetNet AUMC series of 2024 took place at location AMC (Costerzaal) on the 30th of January, where a crowd of about 30 researchers met and got to know the projects of four new young speakers of the network:
- Kaspar Bresser (Sanquin Research), postdoctoral researcher in the group of Monica Wolkers, opened the session with his preliminary work on metabolic enzymes as potential rheostats in T cell. dysfunction, a project for which he recently was awarded a CCA grant.
- Nico Hahn (AGEM/ACS), PhD candidate in the group of Jan van den Bossche, shared with the audience their most recent data on modulation of macrophages by metabolic interventions.
- Ramin Raoof (CCA), postdoctoral researcher in the group of Tuna Mutis and Niels van de Donk, provided a summary of a recently completed project on the role of monocytes in controlling cancer cell metabolism in multiple myeloma.
- The session was closed by Crescenzo Massaro (CCA), postdoctoral researcher in the group of Rubina Baglio, with their first results on high-dimensional immunometabolic profiling using spectral flow analysis with the aim of better personalizing the treatment for cancer patients.
As usual, AGEM organized a very nice catering afterwards where we could enjoy drinks and food while discussing with the participants.
2023
Tuesday February 28th, 2023
Amsterdam UMC, location AMC, Vrijzaal
After the first successful year of ImmunoMetNet Amsterdam UMC series in 2022, a new series kicked off in February 2023 at location AMC for the first time. With an attendance of more than 25 people, many of them new faces joining the network for the first time, the afternoon was filled with very good scientific discussions around the four presented topics. Once again, the stage was reserved for young researchers, in this case:
- Nienke Goedhart (CCA/AII), PhD candidate in the lab of Eric Eldering & Arnon Kater shared her work on decreased mitochondrial metabolism as the driver of T-cell dysfunction in chronic lymphocytic leukemia.
- Iosifina Foskolou (AII/Sanquin), recently incorporated as PI in Sanquin, presented her project about the two enantiomers of 2-hydroxyglutarate and how they differentially regulate cytotoxic T cell function.
- Frouwkje Politiek (AGEM/AII), PhD candidate in Hans Waterham lab presented her work on the mechanisms underlying inflammation in mevalonate kinase deficiency.
- Chiara Montironi (CCA/AII), PhD candidate in the lab of Eric Eldering and Arnon Kater showed her work on how leukemic cells suppress T cell function by inducing pseudohypoxia and autocrine purinergic signaling.
The afternoon closed with a wonderful borrel provided by AGEM, which is always a great opportunity to continue the discussions in a low-key format, one of the goals of these meetings. Besides, by organizing this event at location AMC for the first time, the aim of making the ImmunoMetNet network wider between both locations was further accomplished.
Wednesday November 8th, 2023
Amsterdam UMC, location VUmc, O|2 building
The second and last ImmunoMetNet Amsterdam UMC meeting of the year took place at location VUmc where it could be observed that this community is getting consolidated and grows. We There were presentations by four new young speakers:
- Chun-Xia Yi (AGEM/AII) presented the work of her PhD candidate, Han Jiao, who was scheduled but couldn't make it to the meeting, about the role of microglia in time restricted feeding.
- Jasper Sanders (CCA), PhD candidate in the group of Sarah Derks shared his work using spatial transcriptomics to identify metabolic dysregulation as one of the main drivers of immune suppression in esophageal adenocarcinoma.
- Signe Mosegaard (AGEM/ACS), postdoc in the group of Riekelt Houtkooper, shared her research about human inborn errors of long-chain fatty acid oxidation and their relation to impaired inflammatory responses to TLR4-ligand LPS.
- Alexandros Nianias (CCA), PhD candidate at the lab of Maria Themeli, shared their model of iPSC-derived T cells and explained how reprogramming the metabolic state of this cells can be used to generate better off-the-shelf CAR-T cells.
2022
Tuesday November 29th, 2022
Amsterdam UMC, location VUmc, O|2 building
The ImmunoMetNet AUMC series has started! Instead of the keynote talk that was initially considered, the series was kicked off by ImmunoMetNet initiator Jan Van den Bossche. Next to the scientific talk about the newfound immunometabolism D-2-hydroxyglutarate in macrophages and the plans his lab has with this wonderful molecule, the past and future of ImmunoMetNet was discussed. A short poll at the end of the presentation provided useful insight into what Amsterdam UMC researchers expect from this series. It looks like we are well on track and aligning with the expectations, we will probably schedule the meetings every 3 months (instead of 2 months) and invite an external speaker every once in a while. Drinks and snacks were kindly provided by AGEM and certainly fueled ImmunoMet-networking, which is an important goal of these meetings.
Tuesday December 20th, 2022
Amsterdam UMC, location VUmc, O|2 building
After the successful kick-off for the ImmunoMetNet AUMC series by Jan Van den Bossche (Welcome to the wonderful world of immunometabolism) on November 29th, the first “real” local ImmunoMetNet meeting was organized on December 20. With over 20 participants and some very good discussions during the low-key presentations, this afternoon was certainly a success. We scheduled 4 talks by junior and senior PhD candidates, and one postdoc. The different institutes were well represented;
- Esmée Hoen (AGEM/AII) from the lab of Anita Boelen presented her ongoing work and plans on Thyroid hormone transporters and their role in macrophage activation.
- Felipe Correa-da-Silva (AGEM/Neuro) from Chun-Xia Yi’s group presented on microglia dysfunction in Prader-Willi-Syndrome.
- Beatriz Marton Freire (ACS/AII) shared her work on how beta-2 adrenergic receptor affects metabolic rewiring in macrophages.
- Helga Simon-Molas (CCA/AII) postdoc on the lab of Eric Eldering and member of the ImmunoMetNet organizing committee, presented ongoing work on how T cells are metabolically fueled in chronic lymphocytic leukemia.