The CONQUEST project addresses a major clinical challenge in the treatment of Multiple Myeloma (MM), the second most common form of hematological cancer. While recent progress has been made in MM treatment, the development of resistance to therapy remains a significant barrier to long-term treatment success. Overcoming this resistance is crucial for improving the long-term effectiveness of MM treatments.
CONQUEST's innovative approach combines computational and experimental strategies to optimize the timing and dosing of treatments. The goal is to prevent or delay resistance, potentially transforming MM into a manageable chronic condition.
The research will be conducted in close collaboration with Prof. Dr. Antoine van Kampen from the Department of Bioinformatics at Amsterdam UMC and Dr. Kateřina Staňková from the Evolutionary Game Theory Lab at Delft University of Technology. This interdisciplinary collaboration strengthens the expertise within the project and increases the likelihood of breakthrough results.
Dr. Guikema and Dr. Hoefsloot are confident that their research will yield valuable insights that can contribute to improved treatment strategies for patients with B-cell malignancies. This grant underscores the power of interdisciplinary collaboration between Amsterdam UMC, the University of Amsterdam, and TU Delft in addressing complex medical challenges.