Hans Waterham

DR.

Affiliatie UvA Amsterdam Gastroenterology Endocrinology Metabolism Full Professor, Genetic Metabolic Diseases

Specialization

Functional genetics, Clinical Laboratory Geneticist

Focus of research

Functional genetics and molecular biology of metabolic disorders in general but with focus on inborn errors of isoprenoid/cholesterol biosynthesis and peroxisome biogenesis.

Latest publications

Imaging flow cytometry-based cellular screening elucidates pathophysiology in individuals with Variants of Uncertain Significance
Muffels, I. J. J., Waterham, H. R., D’Alessandro, G., Zagnoli-Vieira, G., Sacher, M., Lefeber, D. J., van der Vinne, C., Roifman, C. M., Gassen, K. L. I., Rehmann, H., van Haaften-Visser, D. Y., Nieuwenhuis, E. S. S., Jackson, S. P., Fuchs, S. A., Wijk, F. & van Hasselt, P., 1 Dec 2025, In: Genome Medicine. 17, 1, 12.
Research output: Contribution to journal › Article › Academic › peer-review
Docosahexaenoic acid prevents peroxisomal and mitochondrial protein loss in a murine hepatic organoid model of severe malnutrition
Horcas-Nieto, J. M., Rios-Ocampo, W. A., Langelaar-Makkinje, M., de Boer, R., Gerding, A., Chornyi, S., Martini, I. A., Wolters, J. C., Wanders, R. J. A., Waterham, H. R., van der Klei, I. J., Bandsma, R. H. J., Jonker, J. W. & Bakker, B. M., 1 Aug 2025, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1871, 6, 167849.
Research output: Contribution to journal › Article › Academic › peer-review
PEX39 facilitates the peroxisomal import of PTS2-containing proteins
Chen, W. W., Rodrigues, T. A., Wendscheck, D., Pedrosa, A. G., Yang, C., Francisco, T. N., Möcklinghoff, T., Zografakis, A., Nunes-Silva, B., Avraham, R. E., Silva, A. R., Ferreira, M. J., Das, H., Koster, J., Neuwirth, S., Bender, J., Oeljeklaus, S., Sondhi, V., Gatsogiannis, C. & Schuldiner, M. & 6 others, Zalckvar, E., Hofmann, K., Waterham, H. R., DeBerardinis, R. J., Azevedo, J. E. & Warscheid, B., 1 Aug 2025, In: Nature Cell Biology. 27, 8, p. 1256-1271 16 p.
Research output: Contribution to journal › Article › Academic › peer-review
All publications

Hans Waterham

Specialization

Focus of research

Imaging flow cytometry-based cellular screening elucidates pathophysiology in individuals with Variants of Uncertain Significance

Docosahexaenoic acid prevents peroxisomal and mitochondrial protein loss in a murine hepatic organoid model of severe malnutrition

PEX39 facilitates the peroxisomal import of PTS2-containing proteins

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