PI
Specialization
- In vitro (co-)culture models of vascular permeability and angiogenesis
- Developing mouse retina as a model for vascular sprouting and tip cell formation
- Oxygen-induced retinopathy model as a model for pathological angiogenesis
- Patient-specific multi-omics approaches
Focus of research
Short Biosketch PI:
Ingeborg Klaassen was trained as a molecular/medical biologist at the University of Groningen and obtained her doctoral degree at the VU University Medical Center Amsterdam (PhD 2001). She is Assistant Professor in the Department of Ophthalmology at Amsterdam UMC location University of Amsterdam since 2012. She is co-principal investigator together with prof. Reinier Schlingemann (ophthalmologist) of the Ocular Angiogenesis group.
Research Interests:
- Molecular mechanisms in retinal vascular disease, including diabetic retinopathy and age-related macular degeneration.
- Special interest in the blood-retinal barrier, blood-brain barrier and microvascular permeability.
- Molecular regulation of angiogenic tip cells/angiogenesis.
- Retinal and cognitive dysfunction in type 2 diabetes
- Vascular in vitro and in vivo models, including iPSC-derived vascular organoids
- Biomarkers and patient-specific multi-omics approaches