Serious mental illness, including schizophrenia, bipolar disorder, and major depressive disorder, has devastating effects on patients and their families. A key clinical challenge is identifying at-risk individuals for prevention. Recent progress in genetics offers unique opportunities. However, new approaches are needed to combine different types of genetic information and capture shared vulnerability across disorders.
With his expertise as a psychiatrist and as a statistical geneticist with a background in mathematics, Dr. Peyrot brings a unique perspective to this challenge, linking clinical needs with advanced quantitative methods.
PersonalRiskProfile
PersonalRiskProfile will integrate diverse genetic data - including common and rare variants, family history, and cross-ancestry prediction patterns - into the unified personalized genetic risk profile (PGRP) method. Unlike most existing approaches that focus on predicting a single disorder, PGRP will generate risk profiles for multiple psychiatric conditions at once, reflecting the reality that these disorders are often correlated in clinical practice.
European Research Council
ERC Starting Grants are among the most prestigious European research awards. They support outstanding early-career researchers in building their own teams and pursuing high-risk, high-gain projects.
Source: Psychiatry Amsterdam