The Netherlands Study of Depression in Older Persons (NESDO) is a multi-site prospective cohort study that investigates the determinants, course, and consequences of depressive disorders in later life. The study includes adults aged 60 years and older and enables direct comparison with depression in younger populations through harmonization with the Netherlands Study of Depression and Anxiety (NESDA).

Between 2007 and 2010, NESDO recruited 510 participants aged 60–93 years across five regions in the Netherlands, including both individuals with depression and non-depressed controls. Baseline assessments comprised questionnaires, interviews, cognitive tests, medical examinations, and biological sampling. Follow-up assessments enable long-term monitoring of the course of depression in older adults.

NESDO has shown that late-life depression is often chronic and recurrent. Higher baseline symptom severity, comorbid dysthymia, and chronic physical illness predict poorer outcomes. The study provides valuable data to improve prevention, treatment, and policy strategies for depression in ageing populations.

NESDO is conducted by a consortium of Dutch mental health institutes and universities. Researchers interested in collaboration or data access may contact nesdo@ggzingeest.nl.

Website: NESDO

Contact person: Brenda Penninx