We provide comprehensive storage for biological materials as well as services related to sample logistics and data management. Materials can be pieces of tissue, cells, serum, plasma, liquor, urine, feces or molecular fractions, such as DNA and RNA.
In our ultra-low temperature freezers and refrigerators, we currently house more than 150 collections, including the HELIUS study on health differences among the residents of Amsterdam with different ethnic origin, the numerous cohorts of Amsterdam Neuroscience, the Liquid Biopsy Center of the Cancer Center Amsterdam, and a large COVID-19 biobank.
An important part of our work is the release of stored materials for actual research projects. We currently support ±150 projects per year with about 50.000 samples.
Organization
Amsterdam UMC Biobank is a core research facility that belongs to the division Laboratory Specialisms. We closely work together with laboratories providing pre- and post-analytic services, including the Central Research Labs (Clinical Chemistry) and the Core Facility Genomics (Human Genetics). The Amsterdam Research Board and a Biobank Council (to be re-established) advise us on biobank matters.
Amsterdam UMC Biobank actively participates in national bio- and databanking initiatives, such as the theme Biobanks & Collections within Health-RI, which currently is the national node of BBMRI. Of particular importance is our long-lasting partnership with the Durrer Center for Cardiovascular Research at location AMC.
Guidelines and ethics
Our activities comply to the Code of Conduct that regulates the use of patient material for research and to relevant legislation, like the General Data Protection Regulation (GDPR).
Collecting clinical data, images, and/or patient material for biobanks requires permission by the ethics committees for biobanks at Amsterdam UMC – for procedures and forms, see the intranet webpage of the CTB.
Services
Biobanking:
Cryostorage of biological materials at +4°C, -70°C, and -196°C
Sample tracking using a biobank management information system (BIMS)
Virtual registry of existing collections
Catalog with overview of collected materials plus basic descriptive information
Logistic support:
Advice about starting biobank collections, including pre-analytic procedures
Infrastructure and equipment for collecting and distributing samples
Support of multicenter initiatives between (non)academic hospitals
Legal-ethical support:
Advice about questions pertaining to legal and ethical issues
Safeguard related to legal and ethical requirements
Support on data management/stewardship:
Customized implementation of infrastructures to collect, analyze, manage, store, archive, and share clinical research data and images
Development of catalogs at study or patient level
Advise in writing data management sections or plans
Facility management:
Access to central freezer rooms at location AMC and VUmc
Backup freezers in case of calamities
Prices
As core facility, we need to earn back costs for technical investments (BIMS, freezers and refrigerators) as well as the effort of our technicians. To this, we handle prices for our services. The storage price also includes the registration and intake of samples. As of 1 January 2023, the following scheme applies for new collections:
| Storage temperature | Storage (per year) | Issue (once) |
| +4 till -70°C | €0,05 – €0,075 | €0,50 |
| -196°C (liquid N₂) | €0,35 | €1,00 |
For studies started before 1 January 2023, the old prices remain current:
| Storage temperature | Intake (once) | Storage (per year) | Issue (once) |
| +4 till -70°C | €0,50 | €0,025 – €0,04 | €0,50 |
| -196°C (liquid N₂) | €1,00 | €0,25 | €1,00 |
Prices refer to standard aliquots of 1-2 ml. Please, ask us for a detailed quotation.
Quality, safety, and environment
Quality management
We have implemented a quality management system for the control and continuous improvement of high-quality storage of biological materials and the facilitation of data management. ISO9001:2015 certification has been obtained and is renewed anually.
Safety
Our services comply to (inter)national standards, such as the PGS15 guideline for the storage of dangerous goods.
Environment
We work with ultra-low temperature freezers that, by using natural hydrocarbon refrigerants with low global warming potential and minimizing energy consumption, reduce environmental impact and save money. Moreover, location VUmc operates a large ultra-low temperature Nordic installation, equivalent to 45 standard freezers. To reduce energy consumption, we set the temperature of all our ultra-low temperature freezers at -70°C by the end of 2022. For storage at -196°C, cost-efficient large-scale vapor phase tanks with very low liquid nitrogen consumption are used.
Team
| Adrie Kromhout | Manager |
| Aran Hartlooper | Application specialist |
| Erik van Iperen | Data specialist |
| Ingrid Grusewski-Kemner | Technician |
| John Wesseling | Technician |
| Jörg Hamann | Facility head |
| Kees Smid | Technician |
| Maureen van der Arend | Technician |
| René Minnaar | Technician |
| Sahar Moukadem | Technician |
Contact
Amsterdam UMC Biobank
Dr. J. (Jörg) Hamann, Head
Ing. A. (Adrie) Kromhout, Manager
Location AMC
Room L01-124/125
Meibergdreef 9
1105 AZ Amsterdam
T: 020-56 66499/61719
Location VUmc
Room ZH0A63
De Boelelaan 1117
1081 HV Amsterdam
T: 020-44 40743