General
On Tuesday July 2, the Tager seminar series will continue with a new lecture by Prof. dr. Michela Deleidi, who works at Institut Imagine in Paris, in the research lab Mechanisms and Therapy of Genetic Brain Diseases.
![Prof. dr. Michela Deleidi](/upload_mm/f/e/1/75306_fullimage_michela-1.jpg)
Lecture
Investigating Genetic Brain Diseases using Brain Organoids
Induced pluripotent stem cell-derived organoids have recently emerged as platforms that more closely mimic the complexity and heterogeneity of tissues. Tissue-specific organoids have been successfully used to model human development and a variety of human diseases. In addition, there are ongoing efforts to improve the complexity of organoid models by incorporating disease-relevant cells.
In this talk, Michela will summarize recent efforts from her laboratory and the research community aimed at implementing brain organoid models coupled with single-cell technologies to study the relationship between rare human brain disorders and common age-related neurodegenerative diseases. In particular, Michela will focus on their recent work on the genetic and functional link between mitochondrial diseases, cell type-specific metabolic changes, and neurodegenerative dementia.
Special attention will be given to discussing the current advantages and limitations of organoid-based modeling of human neurodegenerative diseases. The development of highly controlled human in vitro models will facilitate the analysis of tissue- and cell-specific pathways involved in brain diseases.
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