Vivian de Waard

PhD

Associate Professor, ACS - Atherosclerosis & Ischemic Syndromes Associate Professor, ACS - Heart Failure & Arrhythmias AII - Immunology Affiliatie UvA Associate Professor, Medical Biochemistry

Specialization

Marfan Syndrome, aortic aneurysm development

Focus of research

Perform fundamental and clinical research to develop therapeutics that can reduce vessel wall degradation and thus decrease the growth (rate) and/or rupture risk of aortic aneurysms.

Key publications
Latest publications

Resveratrol Inhibits Aortic Root Dilatation in the Fbn1C1039G/+ Marfan Mouse Model
Hibender, S., Franken, R., van Roomen, C., ter Braake, A., van der Made, I., Schermer, E. E., Gunst, Q., van den Hoff, M. J., Lutgens, E., Pinto, Y. M., Groenink, M., Zwinderman, A. H., Mulder, B. J. M., de Vries, C. J. M. & de Waard, V., 2016, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 36, 8, p. 1618-1626
Research output: Contribution to journal › Article › Academic › peer-review
Orphan nuclear receptor Nur77 affects cardiomyocyte calcium homeostasis and adverse cardiac remodelling
Medzikovic, L., Schumacher, C. A., Verkerk, A. O., van Deel, E. D., Wolswinkel, R., van der Made, I., Bleeker, N., Cakici, D., van den Hoogenhof, M. M. G., Meggouh, F., Creemers, E. E., Remme, C. A., Baartscheer, A., de Winter, R. J., de Vries, C. J. M., Arkenbout, E. K. & de Waard, V., 2015, In: Scientific reports. 5, p. 15404
Research output: Contribution to journal › Article › Academic › peer-review
Beneficial Outcome of Losartan Therapy Depends on Type of FBN1 Mutation in Marfan Syndrome
Franken, R., den Hartog, A. W., Radonic, T., Micha, D., Maugeri, A., van Dijk, F. S., Meijers-Heijboer, H. E., Timmermans, J., Scholte, A. J., van den Berg, M. P., Groenink, M., Mulder, B. J. M., Zwinderman, A. H., de Waard, V. & Pals, G., 2015, In: Circulation. Cardiovascular genetics. 8, 2, p. 383-388
Research output: Contribution to journal › Article › Academic › peer-review
All publications

Vivian de Waard

Specialization

Focus of research

Resveratrol Inhibits Aortic Root Dilatation in the Fbn1C1039G/+ Marfan Mouse Model

Orphan nuclear receptor Nur77 affects cardiomyocyte calcium homeostasis and adverse cardiac remodelling

Beneficial Outcome of Losartan Therapy Depends on Type of FBN1 Mutation in Marfan Syndrome

Menke-Hennekam syndrome; delineation of domain-specific subtypes with distinct clinical and DNA methylation profiles

Doxycycline induces mitochondrial dysfunction in aortic smooth muscle cells

Serine phosphorylation of the RhoGEF Trio stabilizes endothelial cell-cell junctions

Vivian de Waard

Specialization

Focus of research

Resveratrol Inhibits Aortic Root Dilatation in the Fbn1C1039G/+ Marfan Mouse Model

Orphan nuclear receptor Nur77 affects cardiomyocyte calcium homeostasis and adverse cardiac remodelling

Beneficial Outcome of Losartan Therapy Depends on Type of FBN1 Mutation in Marfan Syndrome

Menke-Hennekam syndrome; delineation of domain-specific subtypes with distinct clinical and DNA methylation profiles

Doxycycline induces mitochondrial dysfunction in aortic smooth muscle cells

Serine phosphorylation of the RhoGEF Trio stabilizes endothelial cell-cell junctions

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