Alsya Affandi

PhD

Affiliatie VU Research Associate, CCA - Cancer biology and immunology Research Associate, Molecular cell biology and Immunology

Specialization

Immunology / Dendritic cells / Cancer / Autoimmunity

Focus of research

I am a senior postdoc (NWO Veni laureate) in fundamental and translational immunology with an extensive experience in cancer and autoimmunity research. My research focuses on developing novel therapeutic nanovaccines, by harnessing dendritic cells to drive anti-cancer immune responses or to dampen in autoimmune diseases.

Key publications
Latest publications

Selective tumor antigen vaccine delivery to human CD169⁺ antigen-presenting cells using ganglioside-liposomes
Affandi, A. J., Grabowska, J., Olesek, K., Venegas, M. L., Barbaria, A., Rodríguez, E., Mulder, P. P. G., Pijffers, H. J., Ambrosini, M., Kalay, H., O’Toole, T., Zwart, E. S., Kazemier, G., Nazmi, K., Bikker, F. J., Stöckl, J., van den Eertwegh, A. J. M., de Gruijl, T. D., Storm, G., van Kooyk, Y., & 2 othersden Haan, J. M. M. & O'Toole, T., 3 Nov 2020, In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 117, 44, p. 27528-27539 12 p.
Research output: Contribution to journal › Article › Academic › peer-review
CD169 Defines Activated CD14⁺ Monocytes With Enhanced CD8⁺ T Cell Activation Capacity
Affandi, A. J., Olesek, K., Grabowska, J., Nijen Twilhaar, M. K., Rodríguez, E., Saris, A., Zwart, E. S., Nossent, E. J., Kalay, H., de Kok, M., Kazemier, G., Stöckl, J., van den Eertwegh, A. J. M., de Gruijl, T. D., Garcia-Vallejo, J. J., Storm, G., van Kooyk, Y. & den Haan, J. M. M., 28 Jul 2021, In: Frontiers in immunology. 12, p. 697840 697840.
Research output: Contribution to journal › Article › Academic › peer-review
Low RUNX3 expression alters dendritic cell function in patients with systemic sclerosis and contributes to enhanced fibrosis
Affandi, A. J., Carvalheiro, T., Ottria, A., Broen, J. C. A., Bossini-Castillo, L., Tieland, R. G., Bon, L. V., Chouri, E., Rossato, M., Mertens, J. S., Garcia, S., Pandit, A., de Kroon, L. M. G., Christmann, R. B., Martin, J., van Roon, J. A. G., Radstake, T. R. D. J. & Marut, W., 1 Sept 2019, In: Annals of the rheumatic diseases. 78, 9, p. 1249-1259
Research output: Contribution to journal › Article › Academic › peer-review
All publications

Nanobody-liposomes as novel cancer vaccine platform to efficiently stimulate T cell immunity
Bouma, R. G., Nijen Twilhaar, M. K., Brink, H. J., Affandi, A. J., Mesquita, B. S., Olesek, K., van Dommelen, J. M. A., Heukers, R., de Haas, A. M., Kalay, H., Ambrosini, M., Metselaar, J. M., van Rooijen, A., Storm, G., Oliveira, S., van Kooyk, Y. & den Haan, J. M. M., 20 Jul 2024, In: International Journal of Pharmaceutics. 660, 124254.
Research output: Contribution to journal › Article › Academic › peer-review
In-depth immune profiling of peripheral blood mononuclear cells in patients with pancreatic ductal adenocarcinoma reveals discriminative immune subpopulations
Rodriguez, E., Zwart, E. S., Affandi, A. A., Verhoeff, J., de Kok, M., Boyd, L. N. C., Meijer, L. L., le Large, T. Y. S., Olesek, K., Giovannetti, E., García-Vallejo, J. J., Mebius, R. E., van Kooyk, Y. & Kazemier, G., Jul 2024, In: Cancer science. 115, 7, p. 2170-2183 14 p.
Research output: Contribution to journal › Article › Academic › peer-review
Impaired LAIR-1-mediated immune control due to collagen degradation in fibrosis
Carvalheiro, T., Marut, W., Pascoal Ramos, M. I., García, S., Fleury, D., Affandi, A. J., Meijers, A. S., Giovannone, B., Tieland, R. G., Elshof, E., Ottria, A., Cossu, M., Meizlish, M. L., Veenendaal, T., Ramanujam, M., Moreno-García, M. E., Klumperman, J., Liv, N., Radstake, T. R. D. J. & Meyaard, L., 1 Jun 2024, In: Journal of autoimmunity. 146, 103219.
Research output: Contribution to journal › Article › Academic › peer-review
All publications

Alsya Affandi

Specialization

Focus of research

Selective tumor antigen vaccine delivery to human CD169+ antigen-presenting cells using ganglioside-liposomes

CD169 Defines Activated CD14+ Monocytes With Enhanced CD8+ T Cell Activation Capacity

Low RUNX3 expression alters dendritic cell function in patients with systemic sclerosis and contributes to enhanced fibrosis

Nanobody-liposomes as novel cancer vaccine platform to efficiently stimulate T cell immunity

In-depth immune profiling of peripheral blood mononuclear cells in patients with pancreatic ductal adenocarcinoma reveals discriminative immune subpopulations

Impaired LAIR-1-mediated immune control due to collagen degradation in fibrosis

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Selective tumor antigen vaccine delivery to human CD169⁺ antigen-presenting cells using ganglioside-liposomes

CD169 Defines Activated CD14⁺ Monocytes With Enhanced CD8⁺ T Cell Activation Capacity