General
Scientific advances have made it possible to grow organoids for multiple organ systems. Organoids are tiny, self-organized 3-D tissue cultures grown from stem cells that can replicate much of the complexity of an organ system. Increasingly, organoids are being used to understand interactions between microbes and hosts, deepening knowledge about mechanisms underlying infections, and functioning as novel platforms to explore microbial therapeutics and vaccines.
Our mini symposium on Organoids and Microbes brings together pioneers and scientists in this field from Baylor College in the US, the Hubrecht Institute in Utrecht, and researchers in the Amsterdam UMC for a lively discussion about their ongoing research, as well the scientific opportunities and new directions that this exciting field makes possible.
Program:
| 09:30 - 09:50 | Mary K. Estes (Baylor College of Medicine, United States) | Mini-Guts: Avatars to Understand Human Intestinal Health and Norovirus Infections |
| 09:50 - 10:10 | Ines Garcia Rodriguez (Amsterdam UMC, The Netherlands) | Human based models to study genotype dependent infection of parechovirus A |
| 10:10 - 10:30 | Thomas Roodsant (Amsterdam UMC, The Netherlands) | S. suis translocation across an enteroid monolayer is driven by the presence of CD77-positive cells |
| 10:30 - 10:50 | Wouter de Jonge (Amsterdam UMC, The Netherlands) | Intestinal organoids to model early life nutrition |
| 10:50 - 11:10 | Sashi Ramani (Baylor College of Medicine, United States) | Co-infections (bacterial/viral, viral/viral) in enteroids |
| 11:10 - 11:40 | BREAK | |
| 11:40 - 12:00 | Cayetano Pleguezuelos (Hubrecht Institute, The Netherlands) | Organoids to understand genotoxic pks+ E coli's role in colon cancer |
| 12:00 - 12:20 | Jochem Bernink (Amsterdam UMC, The Netherlands) | Immune-mediated regeneration of the human intestinal epithelium |
| 12:20 - 12:40 | Jianbo Zang (University of Amsterdam, The Netherlands) | Rebuild to understand: organoids-derived gut physiomimetic system for host-microbiome interactions |
Host: Vanessa Harris