General
TN2 stands for Translational Neuroscience Network, and we connect basic and clinical researchers in the field of Translational Neuroscience from all over the Netherlands and beyond. Join their upcoming symposium "The dynamic brain: mind-changing states".
Speakers
Dr. Tomas Knapen on "A systems neuroscience perspective on the effects of psilocybin in the human brain"
How do psychedelics change the computations performed by the human cortex? We recently combined psilocybin, psychophysics, and ultra-high-field (7T) fMRI to examine visual processing within individually mapped cortical topographies. Psilocybin strengthened contextual influences on perception, increasing the Ebbinghaus illusion, while reducing surround suppression in early visual cortex. A divisive normalization model captured these changes through a selective alteration in cortical response modulation, despite largely preserved visual field maps and receptive field sizes. These findings implicate contextual computation as a potentially general mechanism of psychedelic action. More broadly, they illustrate how individual-level, computationally informed 7T imaging can move psychedelic neuroscience beyond global brain dynamics toward mechanistic accounts of perception and experience.
Dr. Daphne Boucherie on “Reorganisation of functional networks by S-ketamine: from neurometabolism to receptor-enriched functional connectivity”
Dr. D. Boucherie completed her PhD at the department of Radiology and Nuclear Medicine at the Amsterdam UMC. During her PhD, she focused on further understanding the different factors (neurobiological and vascular) that influence and underlie the pharmacological MR response to antidepressant medication, such as selective serotonin reuptake inhibitors (SSRIs) and ketamine. Following her PhD, Daphne started as a postdoctoral researcher at the department of Radiology and Nuclear Medicine at the Amsterdam UMC. Currently, her research focuses on investigating the neurobiology of loneliness in young adults, and the effects of technology use thereon.
Dr. Metten Somers
As a psychiatrist at the UMC Utrecht his work focuses mainly on diagnosis and treatment of severe cases of depression, mood instabilities present in bipolar disorder and treatment of psychosis. He is mainly focused on treating persistant complaints with for example electroconvulsiontherapy. He also collaborates with Groningen UMC on research focused on the safety and efficacy of psilocybin in therapy resistant depression.
Programme
| 10:15 | Word of welcome by the TN2 organization |
| 10:30 | Lecture by Tomas Knapen: “A systems neuroscience perspective on the effects of psilocybin in the human brain” |
| 11:00 | Lecture by Daphne Boucherie: “Reorganisation of functional networks by S-ketamine: from neurometabolism to receptor-enriched functional connectivity” |
| 11:20 | Lecture by Metten Somers |
| 11:50 | Panel discussion with all speakers |
| 12:15 | Wrap-up |
Date and Location
Costs and registration
This event is free of charge!
Contact
For questions reach out to neuroscience@amsterdamumc.nl